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FDA approves landmark pancreatic cancer drug that’s shown to improve survival

FDA approves landmark pancreatic cancer drug that’s shown to improve survival

Summary

The U.S. Food and Drug Administration (FDA) approved a new drug called daraxonrasib to treat the most common type of pancreatic cancer. This pill targets a mutated protein causing the cancer and nearly doubles patients' survival time compared to chemotherapy.

Key Facts

  • Daraxonrasib is the first drug to block a mutated protein found in over 90% of pancreatic cancers.
  • It was approved by the FDA more than six months ahead of schedule.
  • The drug nearly doubled median survival to 13.2 months compared to 6.7 months for chemotherapy.
  • The treatment has fewer severe side effects than chemotherapy.
  • The pancreatic cancer study involved 500 patients whose cancer had stopped responding to previous treatments.
  • Pancreatic cancer is hard to detect early and has a low five-year survival rate of 13%.
  • The drug uses a "molecular glue" to stick to KRAS mutations, which were previously considered untreatable.
  • Revolution Medicines, based in California, is also testing this drug technology for other cancers like lung cancer.
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