Scientists Create Cells That Fight Cancer Two Ways—at Fraction of the Cost
Summary
Scientists created special immune cells called AlloESO-T cells that can attack cancer in two ways. These cells are made from engineered stem cells, cost less to produce, and may work better against solid tumors than current treatments.Key Facts
- AlloESO-T cells target cancer using a T-cell receptor that recognizes a protein inside tumor cells called NY-ESO-1.
- They also use natural killer receptors to find and kill stressed cancer cells without relying on NY-ESO-1.
- These cells can be made in large batches from blood-forming stem cells, unlike current therapies made individually for each patient.
- One batch from cord blood stem cells can create trillions of cells, enough for thousands of doses.
- The estimated cost per dose is about $5,000, potentially lower than many existing cancer cell therapies.
- In laboratory and animal tests, AlloESO-T cells showed strong tumor killing, moved toward tumors, and resisted cancer’s immune evasion.
- The cells showed low risks for harmful side effects like graft-versus-host disease and cytokine release syndrome in early tests.
- Further studies are needed to confirm safety, proper dosing, and whether they work well in patients.
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