Ozempic May Reduce Oxygen Supply to Developing Fetuses, Animal Study Finds
Summary
An animal study found that a single dose of semaglutide was followed by lower blood flow to the uterus and reduced oxygen levels in fetal sheep. Researchers said the findings are preliminary and have not been confirmed in humans.Key Facts
- Researchers at Adelaide University gave semaglutide to seven pregnant sheep.
- The sheep were between 113 and 116 days into pregnancies that typically last about 147 days.
- Within two hours, the researchers measured a significant drop in the amount of blood pumped by the mothers’ hearts.
- The change was linked to reduced blood flow to the uterus and lower oxygen levels in the fetuses.
- The study abstract appeared in Heart, Lung and Circulation in August; the full study has not been published.
- Researchers said they do not know what caused the blood-flow changes and are investigating the mechanism in further animal studies.
- Semaglutide is not recommended during pregnancy, and manufacturers and clinical guidelines recommend stopping it two months before conception.
- Researchers said it is not known whether the sheep findings also occur in humans.
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