Ovarian Cancer Is Often Found Late—Scientists Uncover Hidden Early Warning
Summary
Researchers at Hoag Memorial Hospital Presbyterian found elevated blood levels of an RNA molecule called Tu-stroma in women with an early fallopian-tube lesion or high-grade serous ovarian cancer. The finding may help detect early disease that standard imaging can miss, but the study describes a potential detection approach rather than an established screening test.Key Facts
- Tu-stroma is a long non-coding RNA molecule identified by the researchers.
- The study found elevated Tu-stroma levels in the blood of women with serous tubal intraepithelial carcinoma or high-grade serous ovarian cancer.
- Serous tubal intraepithelial carcinoma is a microscopic lesion in the lining of the fallopian tube.
- The lesion can exist without a visible tumor or symptoms, according to study author Esha Madan.
- The researchers said cancer cells can send Tu-stroma to nearby cells in membrane-enclosed particles called extracellular vesicles.
- The study was published in Nature Medicine on November 10.
- About 20 percent of ovarian cancers are found at an early stage, according to the American Cancer Society.
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